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DURECT - 25 Year Stock Price History | DRRX

Historical daily share price chart and data for DURECT since 2000 adjusted for splits and dividends. The latest closing stock price for DURECT as of August 27, 2025 is 1.93.
  • The all-time high DURECT stock closing price was 158.12 on November 06, 2000.
  • The DURECT 52-week high stock price is 2.64, which is 36.8% above the current share price.
  • The DURECT 52-week low stock price is 0.48, which is 75.1% below the current share price.
  • The average DURECT stock price for the last 52 weeks is 0.98.
For more information on how our historical price data is adjusted see the Stock Price Adjustment Guide.
  
DURECT Historical Annual Stock Price Data
Year Average Stock Price Year Open Year High Year Low Year Close Annual % Change
2025 0.8656 0.7908 1.9400 0.4999 1.9300 157.33%
2024 1.1587 0.5550 1.7800 0.5215 0.7500 27.12%
2023 3.8218 3.6000 8.7200 0.5020 0.5900 -82.95%
2022 5.6450 9.7500 9.7500 3.3900 3.4600 -64.91%
2021 16.0516 21.0000 28.7000 8.9560 9.8590 -52.37%
2020 20.0734 26.1500 28.5000 9.6780 20.7000 -45.53%
2019 11.8597 5.4020 38.0000 5.1200 38.0000 686.59%
2018 14.2259 9.2020 25.1000 4.8310 4.8310 -47.59%
2017 12.6894 13.4000 21.0000 7.7580 9.2180 -31.21%
2016 13.7067 20.4000 20.4000 10.1000 13.4000 -39.37%
2015 20.0206 8.3000 32.3000 8.3000 22.1000 180.03%
2014 14.1437 17.3000 22.2000 6.9570 7.8920 -54.38%
2013 12.3986 9.6000 17.5000 7.7080 17.3000 88.04%
2012 9.5235 12.0000 16.6000 6.9410 9.2000 -22.03%
2011 24.2069 35.9000 37.3000 11.5000 11.8000 -65.80%
2010 25.9768 25.6000 36.1500 19.5000 34.5000 39.68%
2009 24.4710 33.0000 33.9000 14.4000 24.7000 -27.14%
2008 46.5304 62.1000 64.3000 28.7000 33.9000 -47.28%
2007 47.9036 43.9000 69.0000 36.8000 64.3000 44.82%
2006 44.8070 50.7000 63.6000 27.6000 44.4000 -12.43%
2005 46.1877 31.2000 71.8000 26.4000 50.7000 54.57%
2004 26.7017 26.4000 42.3000 12.6000 32.8000 31.20%
2003 24.3274 21.2000 40.0000 11.2000 25.0000 23.76%
2002 62.5330 110.5000 116.0000 19.7000 20.2000 -82.57%
2001 88.3904 111.2500 140.0000 40.0000 115.9000 -3.42%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $0.060B $0.002B
Durect Corp. is pioneering the treatment of chronic diseases and conditions by developing and commercializing pharmaceutical systems to deliver the right drug to the right place in the right amount at the right time. Its pharmaceutical systems combine engineering innovations and delivery technology from the medical device and drug delivery industries with its proprietary pharmaceutical and biotechnology drug formulations.
Stock Name Country Market Cap PE Ratio
Chugai Pharmaceutical (CHGCY) Japan $70.099B 26.96
Zoetis (ZTS) United States $68.600B 24.89
Takeda Pharmaceutical (TAK) Japan $47.347B 9.66
Daiichi Sankyo, - (DSNKY) Japan $46.431B 23.80
BeOne Medicines - (ONC) Switzerland $33.857B 0.00
Sandoz Group AG (SDZNY) Switzerland $27.333B 0.00
Summit Therapeutics (SMMT) United States $20.042B 0.00
Merck (MKKGY) Germany $16.317B 10.61
Shionogi (SGIOY) Japan $14.615B 14.64
United Therapeutics (UTHR) United States $13.948B 12.07
Neurocrine Biosciences (NBIX) United States $13.572B 40.49
Orion OYJ (ORINY) Finland $11.336B 27.32
IPSEN (IPSEY) France $11.117B 0.00
Madrigal Pharmaceuticals (MDGL) United States $9.433B 0.00
Eisai (ESAIY) $9.158B 10.33
Corcept Therapeutics (CORT) United States $7.331B 61.57
Grifols, S.A (GRFS) Spain $6.766B 0.00
Ionis Pharmaceuticals (IONS) United States $6.722B 0.00
Stevanato Group S.p.A (STVN) Italy $6.557B 38.66
Ono Pharmaceutical (OPHLF) Japan $5.740B 19.71
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $5.436B 0.00
Soleno Therapeutics (SLNO) United States $3.699B 0.00
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $2.946B 14.00
Crinetics Pharmaceuticals (CRNX) United States $2.913B 0.00
NewAmsterdam Pharma (NAMS) Netherlands $2.837B 0.00
Hypermarcas (HYPMY) Brazil $2.755B 20.71
Catalyst Pharmaceuticals (CPRX) United States $2.440B 8.17
Centessa Pharmaceuticals (CNTA) United Kingdom $2.248B 0.00
Ocular Therapeutix (OCUL) United States $2.144B 0.00
Dyne Therapeutics (DYN) United States $1.903B 0.00
BioCryst Pharmaceuticals (BCRX) United States $1.801B 0.00
Guardian Pharmacy Services (GRDN) United States $1.648B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $1.607B 23.94
Ardelyx (ARDX) United States $1.494B 0.00
Avadel Pharmaceuticals (AVDL) Ireland $1.442B 0.00
Harrow (HROW) United States $1.427B 0.00
ARS Pharmaceuticals (SPRY) United States $1.373B 0.00
Xeris Biopharma Holdings (XERS) United States $1.284B 0.00
Evotec AG (EVO) Germany $1.239B 0.00
Collegium Pharmaceutical (COLL) United States $1.215B 6.64
Enliven Therapeutics (ELVN) United States $1.204B 0.00
Cronos Group (CRON) Canada $0.977B 0.00
Akebia Therapeutics (AKBA) United States $0.819B 0.00
Amylyx Pharmaceuticals (AMLX) United States $0.817B 0.00
Rigel Pharmaceuticals (RIGL) United States $0.747B 7.69
ProKidney (PROK) United States $0.700B 0.00
Theravance Biopharma (TBPH) United States $0.695B 57.50
KalVista Pharmaceuticals (KALV) United States $0.662B 0.00
Organogenesis (ORGO) United States $0.611B 0.00
Relay Therapeutics (RLAY) United States $0.610B 0.00
Siga Technologies (SIGA) United States $0.608B 7.51
Tourmaline Bio (TRML) United States $0.604B 0.00
Bioventus (BVS) United States $0.601B 14.54
Elite Pharmaceuticals (ELTP) United States $0.586B 0.00
USANA Health Sciences (USNA) United States $0.579B 11.87
Savara (SVRA) United States $0.572B 0.00
Xencor (XNCR) United States $0.563B 0.00
Oruka Therapeutics (ORKA) United States $0.555B 0.00
Nektar Therapeutics (NKTR) United States $0.547B 0.00
Zevra Therapeutics (ZVRA) United States $0.528B 0.00
Esperion Therapeutics (ESPR) United States $0.442B 0.00
Nanobiotix S.A (NBTX) France $0.402B 0.00
Aquestive Therapeutics (AQST) United States $0.389B 0.00
Aldeyra Therapeutics (ALDX) United States $0.353B 0.00
Larimar Therapeutics (LRMR) United States $0.320B 0.00
4D Molecular Therapeutics (FDMT) United States $0.305B 0.00
Altimmune (ALT) United States $0.304B 0.00
Tonix Pharmaceuticals Holding (TNXP) United States $0.298B 0.00
Nature's Sunshine Products (NATR) United States $0.291B 18.97
AleAnna (ANNA) United States $0.283B 0.00
Galectin Therapeutics (GALT) United States $0.266B 0.00
Lexeo Therapeutics (LXEO) United States $0.264B 0.00
Heron Therapeutics (HRTX) United States $0.216B 0.00
Lyell Immunopharma (LYEL) United States $0.211B 0.00
Ironwood Pharmaceuticals (IRWD) United States $0.206B 31.75
OmniAb (OABI) United States $0.198B 0.00
Aclaris Therapeutics (ACRS) United States $0.196B 0.00
Korro Bio (KRRO) United States $0.190B 0.00
MediWound (MDWD) Israel $0.182B 0.00
Journey Medical (DERM) United States $0.181B 0.00
China SXT Pharmaceuticals (SXTC) China $0.174B 0.00
Innate Pharma SA (IPHYF) France $0.173B 0.00
MEI Pharma (MEIP) United States $0.171B 0.00
Achieve Life Sciences (ACHV) Canada $0.159B 0.00
Wellgistics Health (WGRX) United States $0.145B 0.00
Inhibikase Therapeutics (IKT) United States $0.137B 0.00
Profound Medical (PROF) Canada $0.135B 0.00
Avalo Therapeutics (AVTX) United States $0.125B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.123B 0.00
Avita Medical (RCEL) United States $0.121B 0.00
Protara Therapeutics (TARA) United States $0.121B 0.00
Cassava Sciences (SAVA) United States $0.109B 0.00
Dominari Holdings (DOMH) United States $0.098B 0.00
Cardiol Therapeutics (CRDL) Canada $0.096B 0.00
Surrozen (SRZN) United States $0.095B 0.00
Champions Oncology (CSBR) United States $0.093B 21.03
BioNxt Solutions (BNXTF) Canada $0.087B 0.00
Pyxis Oncology (PYXS) United States $0.085B 0.00
Liminatus Pharma (LIMN) United States $0.085B 0.00
VAXART, INC (VXRT) United States $0.082B 0.00
Arch Biopartners (ACHFF) Canada $0.078B 0.00
Context Therapeutics (CNTX) United States $0.077B 0.00
PMV Pharmaceuticals (PMVP) United States $0.076B 0.00
Assertio Holdings (ASRT) United States $0.075B 0.00
Unicycive Therapeutics (UNCY) United States $0.075B 0.00
Nutriband (NTRB) United States $0.072B 0.00
Vivani Medical (VANI) United States $0.071B 0.00
Metagenomi (MGX) United States $0.070B 0.00
Prelude Therapeutics (PRLD) United States $0.069B 0.00
Gain Therapeutics (GANX) United States $0.069B 0.00
Karyopharm Therapeutics (KPTI) United States $0.065B 0.00
Inotiv (NOTV) United States $0.060B 0.00
Procaps Group, S.A (PROCF) Luxembourg $0.059B 0.00
Verrica Pharmaceuticals (VRCA) United States $0.056B 0.00
PolyPid (PYPD) Israel $0.054B 0.00
Rafael Holdings (RFL) United States $0.054B 0.00
NRx Pharmaceuticals (NRXP) United States $0.052B 0.00
Jupiter Neurosciences (JUNS) United States $0.052B 0.00
Cumberland Pharmaceuticals (CPIX) United States $0.051B 30.91
Fractyl Health (GUTS) United States $0.051B 0.00
Plus Therapeutics (PSTV) United States $0.050B 0.00
Tempest Therapeutics (TPST) United States $0.049B 0.00
Telomir Pharmaceuticals (TELO) United States $0.048B 0.00
Klotho Neurosciences (KLTO) United States $0.045B 0.00
Century Therapeutics (IPSC) United States $0.044B 0.00
FibroGen (FGEN) United States $0.042B 0.00
Acrivon Therapeutics (ACRV) United States $0.042B 0.00
ElectroCore (ECOR) United States $0.041B 0.00
Mural Oncology (MURA) Ireland $0.036B 0.00
Vivos Therapeutics (VVOS) United States $0.035B 0.00
Reviva Pharmaceuticals Holdings (RVPH) United States $0.035B 0.00
SCYNEXIS (SCYX) United States $0.034B 0.00
Iterum Therapeutics (ITRM) Ireland $0.031B 0.00
CASI Pharmaceuticals (CASI) China $0.028B 0.00
Enlivex Therapeutics (ENLV) Israel $0.026B 0.00
Cosmos Health (COSM) United States $0.025B 0.00
Natural Alternatives (NAII) United States $0.023B 0.00
Citius Pharmaceuticals (CTXR) United States $0.022B 0.00
Relmada Therapeutics (RLMD) United States $0.022B 0.00
Scienture Holdings (SCNX) United States $0.022B 0.00
Incannex Healthcare (IXHL) Australia $0.021B 0.00
Mangoceuticals (MGRX) United States $0.020B 0.00
Ainos (AIMD) United States $0.019B 0.00
Mannatech (MTEX) United States $0.017B 0.00
Lipocine (LPCN) United States $0.017B 0.00
BioLineRx (BLRX) Israel $0.015B 0.00
ProPhase Labs (PRPH) United States $0.014B 0.00
Aptorum Group (APM) United Kingdom $0.013B 0.00
TherapeuticsMD (TXMD) United States $0.013B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.013B 0.00
ESSA Pharma (EPIX) Canada $0.012B 0.00
BioVie (BIVI) United States $0.012B 0.00
Lyra Therapeutics (LYRA) United States $0.012B 0.00
Phio Pharmaceuticals (PHIO) United States $0.012B 0.00
Ernexa Therapeutics (ERNA) United States $0.011B 0.00
Talphera (TLPH) United States $0.011B 0.00
Heatwurx (PCSA) United States $0.011B 0.00
Traws Pharma (TRAW) United States $0.010B 0.02
Carisma Therapeutics (CARM) United States $0.010B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.010B 0.00
CERo Therapeutics Holdings (CERO) United States $0.009B 0.00
TransCode Therapeutics (RNAZ) United States $0.009B 0.00
Biomerica (BMRA) United States $0.008B 0.00
Addex Therapeutics (ADXN) Switzerland $0.008B 0.00
VYNE Therapeutics (VYNE) United States $0.008B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.008B 0.00
NLS Pharmaceutics (NLSP) Switzerland $0.008B 0.00
Vyome Holdings (HIND) United States $0.008B 0.00
Indaptus Therapeutics (INDP) United States $0.007B 0.00
Nuvilex (PMCB) United States $0.007B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.006B 0.00
Aditxt (ADTX) United States $0.005B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.005B 0.00
CDT Equity (CDT) United States $0.005B 0.00
InMed Pharmaceuticals (INM) Canada $0.005B 0.00
Xenetic Biosciences (XBIO) United States $0.004B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.004B 0.00
Clearmind Medicine (CMND) Canada $0.004B 0.00
XORTX Therapeutics (XRTX) Canada $0.004B 0.00
Alaunos Therapeutics (TCRT) United States $0.004B 0.00
Jaguar Animal Health (JAGX) United States $0.004B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.004B 0.00
PainReform (PRFX) Israel $0.003B 0.00
Qualigen Therapeutics (QLGN) United States $0.003B 0.00
Redhill Biopharma (RDHL) Israel $0.003B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.003B 0.00
SHINECO (SISI) China $0.003B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.002B 0.00
SciSparc (SPRC) Israel $0.002B 0.00
Universe Pharmaceuticals INC (UPC) China $0.002B 0.00
TNF Pharmaceuticals (TNFA) United States $0.001B 0.00
Indivior (INDV) United States $0.000B 13.74
4D Pharma (LBPS) United Kingdom $0.000B 0.00
Minerva Neurosciences (NERV) United States $0.000B 1.59
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00
Silence Therapeutics (SLN) United Kingdom $0.000B 0.00